Essential thrombocythemia is one of the myeloproliferative neoplasms with a plethora of thrombohemorrhagic complications.Hydroxyurea has been proven to be an effective treatment for this condition.However, it is not without side effects.We atmas wail herein report 3 patients with essential thrombocythemia treated with hydroxyurea who developed refractory leg ulcers, and we outline their successful management.We also review the literature to shed light on the mechanism bob the boxcutter of this toxicity.
Awareness of this important treatment complication is important to avoid the pitfall of futile invasive interventions.